Molecular Formula | C16H22ClN3 |
Molar Mass | 291.82 |
Density | 1.138±0.06 g/cm3(Predicted) |
Melting Point | 94-97?C |
Boling Point | 173-175 °C(Press: 0.05 Torr) |
Solubility | Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly), Met |
Appearance | Solid |
Color | Pale Yellow to Dark Yellow |
pKa | 10.62±0.19(Predicted) |
Storage Condition | -20°C Freezer |
In vitro study | P. falciparum |
In vivo study | Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame. |
WGK Germany | 3 |
HS Code | 2933497050 |